Natural Killer Cells Mediate Protection against Yersinia pseudotuberculosis in the Mesenteric Lymph Nodes

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Natural Killer Cells Mediate Protection against Yersinia pseudotuberculosis in the Mesenteric Lymph Nodes

Natural killer cells play a crucial role in the initial defense against bacterial pathogens. The crosstalk between host cells infected with intracellular pathogens and NK cells has been studied intensively, but not much attention has been given to characterize the role of NK cells in the response to extracellular bacterial pathogens such as yersiniae. In this study we used antibody-mediated NK ...

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Mesenteric lymph nodes infection with Linguatula serrata nymphs in cattle

871 mesenteric lymph nodes taken from 110 native cattle from Urmia slaughter-house with differentages were examined for Linguatula serrata infection. The lymph nodes were studied based on their colourand consistency. 44% of the cattle were found positive for L. serrata infection. The number of parasitesisolated from each infected lymph node varied from 1 to 69 with a mean of 5.48. There were no...

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Identification of MrtAB, an ABC Transporter Specifically Required for Yersinia pseudotuberculosis to Colonize the Mesenteric Lymph Nodes

A highly conserved virulence plasmid encoding a type III secretion system is shared by the three Yersinia species most pathogenic for mammals. Although factors encoded on this plasmid enhance the ability of Yersinia to thrive in their mammalian hosts, the loss of this virulence plasmid does not eliminate growth or survival in host organs. Most notably, yields of viable plasmid-deficient Yersini...

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YopE specific CD8+ T cells provide protection against systemic and mucosal Yersinia pseudotuberculosis infection

Prior studies indicated that CD8+ T cells responding to a surrogate single antigen expressed by Y. pseudotuberculosis, ovalbumin, were insufficient to protect against yersiniosis. Herein we tested the hypothesis that CD8+ T cells reactive to the natural Yersinia antigen YopE would be more effective at providing mucosal protection. We first confirmed that immunization with the attenuated ksgA- s...

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mesenteric lymph nodes infection with linguatula serrata nymphs in cattle

871 mesenteric lymph nodes taken from 110 native cattle from urmia slaughter-house with differentages were examined for linguatula serrata infection. the lymph nodes were studied based on their colourand consistency. 44% of the cattle were found positive for l. serrata infection. the number of parasitesisolated from each infected lymph node varied from 1 to 69 with a mean of 5.48. there were no...

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ژورنال

عنوان ژورنال: PLOS ONE

سال: 2015

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0136290